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Persona 4 golden marie10/2/2023 ![]() She will often recognize the places you take her, but she can’t seem to remember how or why she knows them. Most of MC’s friends befriend her nonetheless.Īs you begin to peel back more of her story, you learn that Marie’s memories are not intact. It’s unclear whether they sense she isn’t malicious when she is talking or if they just have thick skin. The main party takes very well to Marie, even though she can be aggravatingly blunt with them. Adorably, she tends to mispronounce a lot of words when she doesn’t necessarily understand their meaning. ![]() Marie is naturally curious about the world and will consistently ask MC about the new environments that she ends up in. Personally, I think that her outfit references the fact that she is learning about the world through your experiences together. Society function is a foreign concept to Marie, who takes every opportunity to witness how MC interacts with his friends and the world. Getting to Know MarieĪs you begin to take Marie out of the Velvet Room, she is unique in that she meets all of your main party members. However, if you are after creating a persona that can hit all elemental weaknesses, this is the easiest way to accomplish that. The drawback is that some of the skills are very expensive. If you have a skill you enjoy using or want to teach to a persona who doesn’t learn it naturally, this can be excessively useful. When Marie can replicate them, the advantage comes in, allowing you to pay money to buy infinite copies. You can also give them to Marie, who will copy them, which will destroy them in the process. You can use these items to teach the MC’s persona new battle skills. As you explore the game’s dungeons, you will occasionally find and receive skill cards. While in the Velvet Room, Margaret will explain that Marie provides skill card services. Functions of MarieĪs previously stated, Marie is a Velvet Room resident meaning that she will assist you somehow. These relics are likely based on the motifs of the Velvet Room, as her hat is adorned with a gold button featuring a large “V.” Marie wears fingerless gloves which go up past her elbows. Marie carries a fashionable deep blue bag that matches her hat. She has black and white thigh-high socks under her shin-high, black plaid combat boots. Marie wears an outfit that is reminiscent of a schoolgirl outfit, with a white sleeveless shirt, black neck-tie, and red plaid skirt. After this cryptic conversation is finished, you can continue the game, and Marie will become available as a social link. Margaret from Persona 4 will go on about her, and Marie will tell her to stop, implying she doesn’t want MC to know too much about her. Marie is also said to be an apprentice to the Velvet Room. Margaret introduces Marie as a “young soul” and tells the MC that she has much to learn about human emotions, whatever that means. Marie is sitting just to Igor’s right side and is initially referred to as an “unfriendly-looking girl.” Both the main character and Marie seem to know one another, but neither can recall why. Marie will pop up in the Velvet Room on April 17th, when you enter at Igor’s request. When you get the chance to explore the shopping district for a second, she will also be standing outside the bookstore. Marie picks it up and hands it back to him before walking away. As the main character (MC) walks to the car, he drops a paper as she walks by. You will see Marie for the first time while leaving the station in Inaba for your new home. Let’s begin our Marie Persona 4 guide by meeting her character. Instead, opting to carefully craft a character that seemingly fits the game’s themes and Meta. Atlus didn’t simply inject a character the way that many games do. Special accommodations are made for Marie due to her being added to an already existing story, but she does not feel the least bit contrived. The Aeon arcana and social link represent Marie, and you will be given a chance to explore her story and be allowed to romance her. ![]() As we delve into the details of her Persona character, be aware that there will be massive spoilers beyond this point. While she seems innocuous at first, Marie is a pivotal part of the late-game plot and has her own social link. Among the new Persona 4 content added in the Golden edition is a genuinely mysterious female character named Marie. Persona 4 Golden is a “final mix” remake for the PSP Vita and is now available on PC.
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Red chrome nails10/2/2023 ![]() ![]() She's also experimented with 3D details before, but never quite like this.Īhead, get a closer look at Fox's chrome textured nails. It's clear the reflective finish suits the edgy star, making for an eye-catching mani that's still versatile. In May, she wore pink and silver chrome nails for a twist on the Barbiecore trend, also by Boyce. This isn't the first time (and it surely won't be the last) that Fox has worn the chrome-nails trend in unique and creative ways. "I did white gel extensions with a multicolor, sheer chrome on top, and then I used 3D clear sculpting gel for height and texture." "The inspo was white, chrome, and something magical," Boyce tells POPSUGAR. Festive red chrome nails on background Stock Photo. The final result combined two major nail trends in one: textured accents and chrome. For your Valentines Day manicure, use red nail polish for heart shapes or French tips and while youre at it, incorporate a few other romance-related colors, like pinks and even black. Find Chrome Nails stock images in HD and millions of other royalty-free stock photos. Her fingers featured sharp, stiletto-shaped extensions with 3D swirl detailing on each one. In a video shared by Boyce, Fox's cool, white nails stood out against her warm-toned look. Watch Stephanie Fountain create this red chrome nail design using liquid art red and gloss gel.Young Nails manufactures the highest quality professional nai. Knowing the devil is in the details, Fox's nails were also done to perfection by none other than Brittney Boyce, the star's go-to celebrity manicurist. Her red hair was pulled back and styled into a messy bun with face-framing pieces on either side of her head by celebrity hairstylist Dimitris Giannetos, and celebrity makeup artist Jenna Kristina gave her sultry peach-toned makeup to match. On July 25, the actor's glam team shared a peek at their latest project together, which saw Fox dressed in a sheer, orange-striped dress. Megan Fox's latest look will stop you in your tracks. How to Pick the Best Nail Shape for You 01 of 09 Classic Chrome Nails Getty Images For her Spring 2023 fashion show, London-based designer went with a classic chrome manicure. Red to Black Nail Chameleon Chrome Powder Mirror Powder Multi Chrome Duo Colour Shifting Gradient Dust Nails Crystal Manicure DIY Shimmer ad vertisement by Unicorn4Nails.
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Oddmar full version free download10/2/2023 ![]() Oddmar MOD APK is not like other Viking games, where the main character is strong, heroic and talented. In addition to the image, graphics, design style, and music without weakness, the company’s biggest technique, the key to helping Oddmar maintain the top ten rankings of mobile games for many years since its launch, is the plot and characters. And when the characters do small actions like jungle, wading, ride a horse … each movement is accompanied by different music, making sense. In addition to the typical sounds of battle, in the game, every single note’s weird music made me feel goosebumps. The game’s monsters are very detailed and have an extra sharpness that makes them look real on your phone screen (if you have high-end phones with high graphics chips).Īn indispensable factor associated with Oddmar’s success is the soundtrack. From the images, graphics, the design style full of “bloody smell”, the game space is always “dark and threatening”, it feels like there are always enemies waiting behind. Oddmar MOD APK is something completely different. This can be seen in many of the flopped Viking games. However, it is difficult to win the player with Viking games. Viking Mushroom makes it easy to visualize the Viking theme. You may not be able imagine Oddmar’s name when you hear it. They would like to release the book in 2016 but they are constantly delayed by many issues. Perhaps the company wanted to change its name as the old name was too unlucky. Oddmar MOD APK is the new name for Viking Mushroom. ![]() Oddmar Introduction Android Version 4.0 has received a major upgrade: sound to graphics This game is too complex to be described in a short amount of words. It is available for both PC and iOS, as well as Android mobile apps. Oddmar, has generated a lot of excitement due to the unique story and high-quality graphics. ![]() Oddmar MOD APK is an action game that combines puzzle adventure with action from MobGe, Turkey.
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Good morning thoughts motivational9/28/2023 ![]() In fact, our brains consume a staggering 20% of our oxygen intake. ![]() They need a lot of fuel - and this includes oxygen. Our brains are calorically expensive to maintain. Oxygen is good for the body and brain, and this especially holds true first thing in the morning. But if you really want to get your juices flowing, keep an eye out for the ingredients in Jim Kwik’s brain tea. Of course, there’s nothing wrong with a good ol’ cup of coffee. And lion’s mane, an edible mushroom, is used to boost the immune system and promote neuroplasticity. Ginkgo biloba is a powerhouse antioxidant and has been shown to increase cognitive performance. Gotu kola has been used for many years in Ayurvedic medicine to combat anxiety and increase focus. He calls it brain tea, and for good reason. Where most folks reach for a cup of coffee, Jim brews up a special blend of three important ingredients: gotu kola, ginkgo biloba, and lion’s mane. Jim Kwik, Author of Mindvalley’s Superbrain Program, swears by this one. It may take a week or two for your body to adjust, but soon enough, you’ll find those early mornings aren’t half as bad as they used to be. ![]() The circadian rhythm is the physiological process that contributes to brain wave fluctuations, hormones, and sleep regulation.Īim to wake up at the same time each and every morning, regardless of what you’ve got going on that day. One of the reasons it’s so difficult for some people to wake up early in the morning is because their circadian rhythm is out of whack. So, before we get to our good morning quotes, we’d like to offer a few early morning life hacks to streamline your routine and boost your productivity. And you might be surprised by just how impactful a few small changes can be! Sometimes, if you want something in your life to change, you have to be willing to tweak your daily routine. 3 Ways to Get Your Day Off to a Great StartĮver heard the phrase, “Insanity is doing the same thing over and over again and expecting different results”? This uplifting collection of good morning quotes just might deliver the boost you need to go out there and turn today into your own personal masterpiece.Īnd better yet, we’re going to give you some top-notch tips on how to hack your morning routine so that your brain is firing on all cylinders before you even leave the house. But did you know that there are some tried and true methods for easing the early morning blues? Getting the day off to a solid start is easier said than done - especially when you’re not a morning person. If you’ve got the weight of the world on your shoulders, the last thing you want to do is haul yourself out of bed at the crack of dawn. When times are tough, finding the energy to get out of bed can be even tougher.
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Dragrace9/28/2023 ![]() ![]() The real impact of this moment isn't necessarily the problem that it exposes, but instead, the fact that Kornbread offers a kind of alternative solution to the ways in which Drag Race approaches the lives of its contestants. Trauma that Kerri's conversation – something normally so innocuous in an episode of Drag Race – seems to have brought back to the forefront. None of this is revealed to the other queens when she returns to the Werk Room, she simply talks about the extent to which she "pushed back" a lot of the trauma that comes from talking about family. ![]() Kornbread talks about the struggles of finding acceptance saying "I felt like a mistake," and going so far as to acknowledge the presence of suicidal thoughts (a continuing tragedy in the trans community). ![]() In talking openly and honestly about them, she doesn't just challenge the extent to which the Werk Room – which, shade aside, tries to be the safest of safe spaces for its contestants – is always the best forum for these things, but in acknowledging the weight that these things can carry. In the – relative, compared to a room full of other queens – privacy of the confessional, Kornbread is able to talk about why it is she finds it difficult, and what it means to still have these feelings lingering in the back of her mind. Drag Race UK just taught TV an important lessonīut Kornbread's confessional moment does more than just that, shining a light not only on the difficulty of exploring the pain of the past but in showing the importance of growing and overcoming it at the right pace.In many ways, what Kornbread does is expose a fatal flaw in the Drag Race formula: the tension that exists between talking openly about trauma, and the extent to which those involved in – or overhearing – the conversations, are able to feel comfortable doing so. Kornbread describes herself as "triggered," and while it might be easy to sidestep this because of the ways in which the term has been misused in so much discourse, there's something vital about the ways in which she approaches talking about this topic, and the language that she uses is an important part of that. This moment with Kornbread runs counter to this idea, and reveals the problem of often throwing the queens into a sudden, and potentially very difficult conversation. This moment is striking in what it reveals about the formula of Drag Race, and the problems that are inherent in it – especially for a show that's spent more and more time over the past few seasons trying to protect and inoculate its contestants from the toxicity that they can face online after appearing on the show. Later, in a confessional, she talks about being "triggered" by what was happening, and feeling like she hadn't worked through the things in her past that she first thought she had. And while every now and then, the hinges of production creak with some heavy-handed transitions, these moments are often the things that allow the queens to get closer to one another, and for the audience to be let in on the lives of the people who bring their all to the stage week after week. The structure of each episode often includes a deep meaningful chat (DMC) between contestants as they get ready to bring it to the runway in a maxi challenge. But for those who don't get that far into the competition, they talk through their issues in The Werk Room. This tends to culminate in the pageantry of finalists talking to images of their younger selves about the things they wish they knew, and the journeys they'll go on. Specifically, because of her Fame Games crowning, no other queen in any of the franchises has this combination of accolades, and that makes LaLa Ri a force all her own.It's what makes a contestant like Jan something of an outlier she was always optimistic, at home in herself, and never really had to deal with the issue of an Inner Saboteur (a Ru-ism for the voice in a queen's head telling them that they aren't good enough). She won both the golden boot, an award given to queens for having the worst outfit on their season, the title of Miss Congeniality on season 13, an award where queens vote for which of their fellow contestants is the most “congenial,” and now the title of Queen of the Fame Games, given to her by the fans. LaLa Ri just might be the most decorated queen in all of Drag Race’s many franchises and spin-offs when it comes to awards. Drag Race All Stars is often seen as a chance for redemption for many queens by fans, and, considering that LaLa Ri was originally awarded for having the worst dress in her original season where she wore a black leotard with pink and lavender party favor bags hot glued to it (a moment that was both confusing and iconic), it’s very fitting that she would be the queen to win a competition for who was the best dressed according to fans.
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Astropad studio for mac os9/28/2023 ![]() ![]() Any unused portion of a free trial period will be forfeited when the user purchases a subscription. No cancellation of the current subscription is allowed during active subscription period. Subscriptions may be managed by the user and auto-renewal may be turned off by going to the user's Account Settings after purchase. Your subscription will automatically renew unless canceled at least 24 hours before the end of the current period. ![]() Subscriptions will be charged to your credit card using your iTunes account. PC: Windows 10 64-bit, build 1809 or later.Color Corrected: True to your source material with color corrected output and retina resolution.Apple Pencil Optimized: Designed exclusively for the precision of Apple Pencil.Velocity Control: Analyzes network conditions dozens of times per second to balance image quality and latency.Keyboard Support: Access our built-in keyboard or use your own Bluetooth keyboard.Wifi & USB: Use your iPad as a graphics tablet plugged in or wirelessly.Liquid Extreme: Up to 5x faster than baseline Liquid.Pinch to Zoom: Pinch to zoom and pan in Mac Apps.Syncing of your settings across your devices.Regular updates with features and improvements.Shortcut Sets: Sidebar shortcuts automatically adapt to match whatever Mac app you’re working in.Magic Gestures: Create your own gesture shortcuts with touch-Pencil combinations.With complete workspace customization, Studio allows artists to work faster and more efficiently, with the freedom to work in the studio, at home, or on-the-go.īuilt for creative professionals with features like: Start a free 14-day trial today!Īstropad Studio is the ultimate wireless drawing tablet, designed for the most demanding creative work. Go beyond a graphics tablet with Astropad Studio.
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Bluetooth mechanical typewriter keyboard9/28/2023 ![]() Covers hardware malfunction. Not including accessories, and accidental use and damage. Battery Capacity 2100mAH, Woking time approximately up to 8 hours Specifications: Keycap, Diameter 15cm x 10cm. ZYQM Retro Typewriter Mechanical Wireless &Wired Keyboard with Tablet Stand, Bluetooth Connection, Artistic Dot Keys (White) 4.3 out of 5 stars 94 1 offer from 399. FINEDAY, FINEDAY Mall, FINEDAY Keyboard, Keyboard, Retro Keyboard, Typing, Retro Bluetooth keyboard, Mechanical Keyboard, Retro Bluetooth Mechanical.Our panels are made by aluminium alloy metal electroplated wood grain or matt finish, matt black pull rods and rollers, and electroplated spherically dished keys are crafted for the shape of your fingertips. Revisit retro style by modern technology.You can also adjust the volume and brightness of the light by twisting the wheels. You can adjust the backlight Led lights mode by pulling the lever, which is interesting when working. Keychron K1 Wireless mechanical keyboard has included keycaps for. Accelerate the speed of typing and enjoy the "Click" feeling of the old royal typewriter Please drop your email on Notify Me When Available if the product model is out of stock. Blue Tactile Switch: the audible click sound is so good and brings you an excellent tactile bump feel.Integrated Tablet Stand: easy and convenient to hold your iPad, tablets and smartphones. ![]() Black Keyboard in Multi Colour LED Backlight. This item: FINEDAY Keyboard 2.0, Red Switch, Retro Wireless Mechanical Keyboard, Typewriter Designed, Full 104 Keys with Bluetooth 5.0 & USB up to 4 Devices, Wired & Wireless for Desktop PC/Laptop Mac/Phone.LED Dynamic Backlight: boost your typing accuracy at night and be more enjoyable while working or playing games.Pair With Up To 3 Devices Simultaneously: allow to connect with 3 devices and switch between with shortcuts, increasing your productivity greatly.Windows /iOS / Android System Supported: Able to connect with iPad Pro, iPhone, and other devices. TISHLED Typewriter Keyboard Wireless Bluetooth 5.0 Retro Aesthetic Cute Kawaii Round Keycaps 106-Key Num Pad Clicky Mechanical Feeling with Pad/Phone Holder for Windows/Mac OS/Android/iOS (Midnight) 126 STypical: 41.Both Bluetooth Wireless And USB Wired Connectivity are Supported: suited for all kinds of usage scenarios. Classic Retro 83 Keys Typewriter Inspired Design Keyboard.Includes 6 Months Limited Hardware Local Warranty by Seller.*Only the Black keyboard has colouful LED light. While many typewriter keyboards stand out, not all of them stand out as much as the vibrant Grenf Wireless Bluetooth Typewriter Keyboard. Choice of 4 colours, Black, Wood, White or Pink. Qwerkywriter S Typewriter Mechanical Keyboard.
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Gopro on a drone9/28/2023 ![]() ![]() The camera continues GoPro’s commitment to quality, versatility, and blistering performance. ![]() Pablo Lema, GoPro VP of Product, calls Bones a “no-compromise” solution for FPV piloting. The cover lens is replaceable, while also being compatible with third-party Hero9 Black and Hero10 Black ND filters for reducing the camera shutter speed to cinematic levels. The body Woodman is talking about is a well-ventilated, semi-durable enclosure that promotes continuous airflow cooling for long captures or flights. Here’s Woodman:īones delivers Hero10 Black image quality and performance in a lightweight body that is ideal for aerial cinematography. GoPro founder and CEO Nicholas Woodman calls the new camera an important step in GoPro’s strategy to leverage the company’s core camera-technology to produce derivative products that address the needs of a specific audience of customers. It can capture cinematic 5K 4:3 video at 30fps, 4K 4:3 video at 60fps, and 2.7K 4:3 video at a super-slow 120fps. At 54 grams, the Hero10 Black Bones is the lightest GoPro ever – providing only the essentials for FPV drone pilots. GoPro’s latest offering takes care of all that and more. One particular problem that many would encounter is that of the camera overheating, especially during takeoff and landing. So, we all love a GoPro on an FPV drone, but this DIY process that pilots have been following to make that happen? It’s rather complicated. Can anyone forget the Minneapolis bowling alley video that went viral? Or the recent flight through the Tesla Gigafactory? The results, though, have been pretty amazing. They strip down as much weight as they can, sometimes going as far as sawing the GoPro apart to engineer a better solution. But pilots don’t just strap on a GoPro camera to their small, cinewhoop-style drones. It’s no secret: GoPro is the first choice for most in the First-Person-View (FPV) drone world.
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Nightowl security system add ons9/28/2023 ![]() For this method, your Smart Device and Recorder must be on the same network.Ĥ. The App automatically searches for any Recorder on your network. Please log in to the App and tap “ Add Device.”ģ. Once connected, please follow the steps below:ġ. NOTE: If you do not remember your password, tap “ Forgot Password” and see section 1E Password Reset.īefore proceeding, please ensure that your Recorder is connected to the Internet using the included Ethernet cable. Enter the email address and password used for setup and tap “ Sign In.” Open the Night Owl Connect App from your Smart Device and tap “ Sign In.”ī. If you do not receive the email, tap “ Resend.”Ĭongratulations! Your Night Owl Connect account has been successfully created and verified.Ī. NOTE: You will not be able to log in to the App without confirming your email address. Tap “Verify” to continue.Ĭopy and paste the verification code into the Code field. Enter the code that is shown in your email into the Code field within the app. Sign into your mailbox and locate the verification email. Tap “ OK” to confirm your account information.Į. NOTE: This is ONLY the password for the Night Owl Connect App, not the password for your DVR/NVR or device.ĭ. The password can be any alphanumeric combination between 6 and 20 characters. Now you will need to type a valid email address, create a password and confirm the password. Next, you must agree to the terms and conditions to use the App. NOTE: Before you continue with the initial setup of the Night Owl Connect App and product pairing, ensure that your Wi-Fi router is transmitting signals at 2.4Ghz band.Ĭurrently, some products are not compatible with Wi-Fi signals of 5Ghz or above.ī. Go to the Google Play Store (Android) or App Store (iOS) to download and install the Night Owl Connect App on your Smart Device. However, the steps will be the same!īasic setup and troubleshooting for the Night Owl Connect Mobile App.Ī. This troubleshooting guide was accurate at the time it was created, but new firmware updates may not be reflected. Google Home (For Compatible Devices Only) CMS (Control Management Software) For Remote Viewing on a PC or Macģ. Connecting a DVR/NVR/Wi-Fi NVR after a Password ResetĢ. Forgot your Night Owl Connect App Password Mobile App (iOS and Android Smart Devices) Important to know: if you choose to give someone equal responsibility, they’ll be able to do everything you can in your OVO account.1. Just call 03 or our landline number 01179 303 100. Our Bristol-based team are available Monday to Friday between 8am and 8pm, and on Saturdays between 9am and 5pm. Our friendly team will then talk you both through the process, and get everything set up for you. You’ll both need to be on the call, unless you’ve already added the person as a name previously. We can’t sort this out by email – whoever you’d like to share your account with will need to call us. This is a bit more complex, as the person will assume equal responsibility for any debts you might build up. How to add someone to your account with equal responsibility ![]() ![]() If you email, it usually takes less than 3 working days. If you call, their name can be added instantly. Just call or email us to give their details, including their date of birth. How to add someone to your account as a nameĪdding someone to your account as just a name, with no financial responsibility, is easy. If you want to share responsibility, you and the person who you'd like to share with will need to call us. Equal responsibility – this is someone who can contact us and make decisions, and has equal financial liability for any debts.Īnyone who is a UK resident over 18 years of age.As a name – this is someone who can contact us and make decisions, but has no financial liability.There are 2 different ways to add people to your energy account: Or, if you need extra support, you could add your carer or other people who assist you. This means you could add your partner or housemate. Absolutely! It’s easy to add other key people to your OVO account.
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Dato dxd9/28/2023 ![]() ![]() Patients without actionable genomic alterations were previously treated, concurrently or sequentially, with platinum-based chemotherapy and a prior PD-1 or PD-L1 inhibitor. TROPION-Lung01 is a global, randomised, multicentre, open-label Phase III trial evaluating the efficacy and safety of datopotamab deruxtecan (6.0 mg/kg) versus docetaxel (75 mg/m 2) in patients with locally advanced or metastatic NSCLC, with or without actionable genomic alterations, treated with at least one prior therapy. 6 There are currently no TROP2-directed ADCs approved for the treatment of patients with lung cancer. TROP2 is a protein highly expressed in a large majority of lung cancers. 3-5 For decades, chemotherapy has been the last treatment available for patients with advanced NSCLC in the absence of other treatment options and despite limited effectiveness and known side effects. 1,2 While immunotherapy and targeted therapies have improved outcomes in the 1st-line metastatic setting, most patients eventually experience disease progression and receive chemotherapy. More than one million people worldwide are diagnosed with advanced NSCLC each year. The data will be presented at a forthcoming medical meeting and shared with health authorities. Patients without actionable genomic alterations were previously treated, concurrently or sequentially, with platinum-based chemotherapy and a PD-1 or PD-L1 inhibitor. Patients with actionable genomic alterations were previously treated with platinum-based chemotherapy and an approved targeted therapy. TROPION-Lung01 enrolled patients with and without actionable genomic alterations, such as EGFR and ALK. There are currently no TROP2-directed ADCs approved for the treatment of patients with lung cancer. 3-5 TROP2 is a protein highly expressed in a large majority of lung cancers. We plan to share these data with regulatory authorities to discuss next steps.” Ken Takeshita, MD, Global Head, Oncology R&D, Daiichi Sankyo, said: “We are encouraged by the statistically significant results of the dual primary endpoint of progression-free survival seen with datopotamab deruxtecan and look forward to the final overall survival analysis. ![]() These first Phase III trial results from the datopotamab deruxtecan clinical programme provide compelling evidence for the potential role this TROP2-directed antibody drug conjugate can play in treating patients with lung cancer.” Susan Galbraith, Executive Vice President, Oncology R&D, AstraZeneca, said: “With TROPION-Lung01, we met the dual primary endpoint of progression-free survival, challenging the entrenched standard of care in a previously treated and unselected patient population that has long deserved an alternative to chemotherapy. Some Grade 5 events were observed.ĭatopotamab deruxtecan is a specifically engineered TROP2-directed DXd antibody drug conjugate (ADC) being jointly developed by AstraZeneca and Daiichi Sankyo. All grade interstitial lung disease was generally consistent with prior clinical trials, with the majority being low grade. The safety profile of datopotamab deruxtecan was consistent with previous clinical trials with no new safety signals identified. The investigators and participants will remain blinded to the results. The trial will continue as planned to assess OS with greater maturity. Positive high-level results from the TROPION-Lung01 Phase III trial showed datopotamab deruxtecan (Dato-DXd) demonstrated a statistically significant improvement for the dual primary endpoint of progression-free survival (PFS) compared to docetaxel, the current standard of care chemotherapy, in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with at least one prior therapy.įor the dual primary endpoint of overall survival (OS), the data were not mature and an early trend was observed in favour of datopotamab deruxtecan versus docetaxel that did not meet the prespecified threshold for statistical significance at this interim analysis. Partnerships, alliances and recognition. |